Game Mechanics

the economic layer is the most important, but the trickiest to influence
See: Ludopolis Traders, Economic Systems, The Goods Report, Strategies for Manipulating Trade

understanding the reasons that people choose where to live will help you develop the largest cities
See: Ludopolis Citizens, Happiness

city planning is your main tool for influencing immigration and the economy
See: City Mechanics, Survival Walkthrough

careful management of your limited time is the foundation of success
See: Ludopolis Players, Gems, Yellow and Green Actions, Moving Your Pawn

placing new cities allows you to influence the underlying structure upon which players move, citizens immigrate, and traders trade
See: Board game basics, Terrains, City Placement

(In addition to these five layers, there are two more game layers of Ludopolis that are not currently activated.)